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[4-14] 生物膜与人类疾病前沿论坛:DOT1L is a melanocyte lineage specific tumor suppressor
  发布日期:2017-04-12  |  来源:膜生物学国家重点实验室  |      

  报 告 人: Rutao Cui, Professor 
  单 位:波士顿大学药理系副主任
  报告题目:DOT1L is a melanocyte lineage specific tumor suppressor 
  报告时间:2017年4月14号下午4点 
  报告地点:A601 
  邀 请 人:周光飚 
  报告简介: 
  The DOT1L gene was found overlapping with one frequent deletion region and somatic missense mutations with deleterious effects occur at significantly higher frequency than expected by chance in human melanomas. Specific mutations inactivate DOT1L methyltransferase enzyme activity leading to reduced H3K79 methylation. Importantly, in the absence of DOTL1, UVR-induced DNA damage is inefficiently repaired such that DOT1L loss promotes melanoma development in mice after exposure to ultraviolet radiation (UVR). 
  Selected Publications: 
  Cui R, et al. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell, 2007, 128, 853-864. 
  Yang G, xx, Cui R. Inhibition of PAX3 by TGF-β modulates melanocytes viability. Molecular Cell, 2008, 32: 554-563. 
  Cao J, xxx, Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Molecular Cell, 2013, 51; 409-422. 
  Cao J, xxx, Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Molecular Cell, 2013, 51; 409-422. 
  Wan L, xx, Cui R. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017; 7:424-441. 
  联系人:侯国丽 6480 7313

 


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