宋默识，中国科学院动物研究所器官再生与智造全国重点实验室研究员，长期从事心脏衰老及相关疾病的机制与干预研究。2011年于瑞典卡罗琳斯卡医学院获医学硕士学位，2015年于美国圣路易斯华盛顿大学获理学博士学位，2016至2018年于美国斯坦福大学从事博士后研究；2018年加入中国科学院动物研究所，成立线粒体与疾病研究组并担任研究组组长。课题组基于人心血管细胞衰老模型和动物心血管衰老及相关疾病模型，解析心血管衰老的分子机制，发现心血管衰老的生物标记物，开发心血管衰老及相关疾病的干预策略。发表论文109篇，总引用逾万次，H指数51。近五年，以通讯作者 (含共同) 在Cell、Nature Aging (x3)、Circulation Research (x2)、Nature Communications (x2)、Cell Research、Advanced Science (x3)、iMeta、Nucleic Acids Research等发表论文34篇，平均影响因子>13。申请发明专利28项，授权10项。

心脏衰老及相关疾病的机制与干预

国家重点研发计划项目，主持

国家自然科学基金重大研究计划培育项目，主持

中国科学院稳定支持基础研究领域青年团队计划，骨干

国家重点研发计划项目青年项目，主持，已结题

北京市自然科学基金杰出青年科学基金项目，主持，已结题

国家自然科学基金青年科学基金项目（B类），主持，已结题

国家自然科学基金面上项目，主持，已结题

中国科学院A类战略性先导科技专项子课题，主持，已结题

国家自然科学基金创新研究群体，骨干，已结题

1. Yang C, Du H, Liu S, Xu P, Wang Y, Zhou Y, Yuan H, Li Y, Shen J, Yuan X, Li M, He C, Zhang J, Xiao Y, Bi J, Hou Y, Zang J, Gao Z, Song M*. Targeting Age-related LINE-1 Activation Alleviates Cardiac Aging. Nature Aging (Cover Story). 2026 Jan 22.
2. Du H, You X, Zhang J, Liu S, Zhou Y, Wang Y, Yang C, Meng Y, Liu X, Zhang H, Li Y, Shen J, Yuan H, Xu P, He C, Xiao Y, Gao Z, Zang J, Wei T*, Song M*. CAR Macrophages Engineered In Vivo for Attenuating Myocardial Ischemia-Reperfusion Injury. Circulation Research (Featured Article). 2025 Aug 29;137(6):846-859.
3. Xiao Y, Zhang H, Liu X, Xu P, Du H, Wang J, Shen J, Li Y, Wang Y, He C, Feng H, Liu J, Zhou Y, Liu S, Gao Z, Zang J, Bi J, Tang TS, Gu Q, Wei T, Wang J, Song M*. Medium From Human iPSC-Derived Primitive Macrophages Promotes Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Nature Communications. 2025 Mar 27;16(1):3012.
4. Du H, Liu X, Shen J, Yuan H, Zhang H, Xi G, Li Y, Wang Y, Zhang J, Yang C, Xu P, Wang J, Wang F, Liu S, Zhou Y, Gu Q, Lu J, Wei T, Gao Z, Zang J, Wang J*, Song M*. Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury. Advanced Science (Frontispiece Article). 2025 Mar 16:e2417827.
5. Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*, Song M*, Zhang W*, Qu J*, Liu GH*. Systematic Profiling Reveals Betaine as an Exercise Mimetic for Geroprotection. Cell. 2025 Jun 25:S0092-8674(25)00635-X.
6. Wang Y, Li Y, Zhou Y, Zhang H, Zang J, Yang C, Gao Z, Hou Y, Song M*. Nynrin Enhances Cardiac Function by Inhibiting Mitochondrial Permeability Transition Pore Opening Upon Myocardial Ischemia/Reperfusion Injury. Journal of Molecular and Cellular Cardiology. 2025 Dec;209:93-103.
7. Xiao Y, Xu P, Bi J, Song M*. Human iPSC-Derived Self-Assembled Cardiac Organoids for Evaluating Drug Developmental Cardiotoxicity. Life Medicine. 2025;4(4):lnaf018.
8. Wang J, Du H, Xie W, Bi J, Zhang H, Liu X, Wang Y, Zhang S, Lei A, He C, Yuan H, Zhang J, Li Y, Xu P, Liu S, Zhou Y, Shen J, Wu J, Cai Y, Yang C, Li Z, Liang Y, Zhao Y, Zhang J*, Song M*. CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury. Circulation Research (Cover Story). 2024 Oct 28.
9. Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*. Prophylactic Supplementation With Lactobacillus reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury. Advanced Science (Frontispiece Article). 2024 Mar 15:e2307233.
10. Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J*, Song M*. Prophylactic Supplementation With Bifidobacterium infantis or Its Metabolite Inosine Attenuates Cardiac Ischemia/Reperfusion Injury. iMeta. 2024 Jul 2;3(4):e220.
11. Xia B, Shen J, Zhang H, Chen S, Zhang X, Song M*, Wang J*. The Alternative Splicing Landscape of Infarcted Mouse Heart Identifies Isoform Level Therapeutic Targets. Scientific Data. 2024 Oct 18;11(1):1154.
12. 王佳琬, 李裕静, 张浩, 陈思琪, 王语涵, 宋默识*.线粒体稳态失衡与心脏衰老及相关疾病[J]. 中国科学：生命科学. 2024, 54(2):260-282.
13. Aging Biomarker Consortium, Zhang W, Che Y, Tang X, Chen S, Song M*, Wang L*, Sun A*, Chen H*, Xu M*, Wang M*, Pu J*, Li Z*, Xiao J*, Cao C*, Zhang Y*, Lu Y*, Zhao Y*, Wang Y*, Zhang C*, Shen T*, Zhang W*, Tao L*, Qu J*, Tang Y*, Liu GH*, Pei G*, Li J*, Cao F*. A Biomarker Framework for Cardiac Aging: the Aging Biomarker Consortium Consensus Statement. Life Medicine. 2023 Oct; 2(5): lnad035.
14. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing Heterochromatin by APOE Mediates Senescence. Nature Aging. 2022 Apr;2(4):303-316.
15. Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR Exerts Differential Levels of Metabolic Control in Human Embryonic, Mesenchymal and Neural Stem Cells. Protein Cell. 2022 Sep;13(9):676-682.
16. Gou B, Chu X, Xiao Y, Liu P, Zhang H, Gao Z, Song M*. Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells. Frontiers in Cardiovascular Medicine. 2022 May 9;9:900978.
17. Shen J, Liu GH*, Song M*. Potential Approaches for Intervening Aging. National Science Open. 2022;1(2):20220021.
18. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*. SIRT3 Consolidates Heterochromatin and Counteracts Senescence. Nucleic Acids Research. 2021 May 7;49(8):4203-4219.
19. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2021 Apr;31(4):415-432.
20. Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. FOXO3-engineered Human Mesenchymal Progenitor Cells Efficiently Promote Cardiac Repair after Myocardial Infarction. Protein Cell. 2021 Feb;12(2):145-151.
21. Zhang J, Liu GH*, Qu J*, Song M*. Treating Osteoarthritis Via Gene Therapy With Rejuvenation Factors. Gene Therapy. 2020 Aug;27(7-8):309-311.
22. Wang Y, Li Y, He C, Gou B, Song M*. Mitochondrial Regulation of Cardiac Aging. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019 Jul 1;1865(7):1853-1864.
23. Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. CRISPR/Cas9-mediated Gene Knockout Reveals a Guardian Role of NF-κB/RelA in Maintaining the Homeostasis of Human Vascular Cells. Protein Cell. 2018 Nov;9(11):945-965.
24. Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metabolism. 2017 Dec 5;26(6):872-883.e5.
25. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-Mediated Mitophagy Directs Perinatal Cardiac Metabolic Maturation in Mice. Science. 2015 Dec 4;350(6265):aad2459.
26. Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 2015 Jul 31;117(4):346-51.
27. Song M#, Matkovich SJ#, Zhang Y, Hammer DJ, Dorn GW 2nd. Combined Cardiomyocyte PKCδ and PKCε Gene Deletion Uncovers Their Central Role in Restraining Developmental and Reactive Heart Growth. Science Signaling. 2015 Apr 21;8(373):ra39.
28. Song M, Dorn GW 2nd. Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart. Cell Metabolism. 2015 Feb 3;21(2):195-205.
29. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts. Cell Metabolism. 2015 Feb 3;21(2):273-286.
30. Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. Circulation Research. 2014 Jul 18;115(3):348-53.