韩玉岭，博士，中国科学院动物研究所干细胞与生殖生物学国家重点实验室研究员，博士生导师。2013年于南开大学生命科学学院获学士学位，2019年获中国科学院生物物理研究所博士学位。同年赴康奈尔大学威尔医学院从事博士后研究。2024年1月全职加入中国科学院动物研究所，研究方向是病毒与宿主相互作用的分子机理。通过以胚胎干细胞和诱导多能干细胞分化的多种组织细胞/类器官为模型，研究病毒感染，并筛选潜在的抗病毒药物。以第一作者或共同一作发表论文10篇，代表论著包括Nature (2021) ，Cell (2019) ，Nature Methods (2022) ，Cell Stem Cell (2020, 2022, 2024) ， Circulation Research (2021, 2022) 等，总引用1600余次。

病毒感染严重威胁人类健康。利用人类胚胎干细胞和多能干细胞分化不同组织细胞/类器官研究病毒感染，可以克服传统细胞系对复杂的人体细胞和器官系统建模的局限。本课题组利用干细胞分化的类器官来研究传染性疾病，结合多组学测序技术和高通量药物筛选平台，深入研究病毒与宿主相互作用的机制，探索潜在的治疗策略。

1. Han Y^#, Duan X^#, Yang L^#, Nilsson-Payant BE^#, Wang P^#, Duan F^#, Tang X^#, Yaron TM^#, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen DT, Xu D, Wang X, Jessurun J, Borczuk A, Huang Y, Johnson JL, Liu Y, Xiang J, Wang H^#, Cantley LC^*, tenOever BR^*, Ho DD^*, Pan FC^*, Evans T^*, Chen HJ^*, Schwartz RE^* and Chen S^*. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021; 589: 270-275
2. Wang X^#, Xuan Y^#, Han Y^#, Ding X, Ye K, Yang F, Gao P, Goff SP and Gao G^*. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Cell. 2019; 176:625-635 e14.
3. Han Y^#, Tan L^#, Zhou T^#, Yang L^#, Carrau L^#, Lacko LA, Saeed M, Zhu J, Zhao Z, Nilsson-Payant BE, Lira Neto FT, Cahir C, Giani AM, Chai JC, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Zhang T, Koo S, Tan C, Danziger R, Ba Q, Feng L, Chen Z, Zhong A, Wise GJ, Xiang JZ, Wang H, Schwartz RE, tenOever BR, Noggle SA, Rice CM, Qi Q, Evans T and Chen S^*. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022; 29:1475-1490 e6.
4. Yang L^#, Han Y^#, Nilsson-Payant BE^#, Gupta V^#, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffre F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC^*, Ho DD^*, tenOever BR^*, Evans T^*, Schwartz RE^* and Chen S^*. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020; 27:125-136 e7. Best of Cell Stem Cell 2020.
5. Han Y^#, Zhu J^#, Yang L^#, Nilsson-Payant BE^#, Hurtado R, Lacko L, Sun X, Gade AR, Higgins CA, Sisso WJ, Dong X, Wang M, Zhengming Chen, Ho DD, Pitt GS, Schwartz RE^*, tenOever BR^*, Evans T^* and Chen S^*. SARS-CoV-2 infection Induces Ferroptosis of Sinoatrial Node-like Pacemaker Cells. Circ Res. 2022 130:963-977. Circulation Research Best Manuscript 2022.
6. Han Y^#, Yang L^#, Lacko L and Chen S^*. Human Organoid Models to Study SARS-CoV-2 Infection. Perspective, Nature Methods. 2022 4:418-428.
7. Yang L^#, Han Y^#, Jaffre F^#, Nilsson-Payant BE^#, Bram Y^#, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Chen Z, Xiang J, Ho DD, tenOever BR^*, Schwartz RE^*, Evans T^* and Chen S^*. An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circ Res. 2021 129:33-46. Cover story
8. Yang L^#, Kim TW^#, Han Y^#, Nair MS^#, Harschnitz O^#, Zhu J^#, Wang P^#, Koo SY, Lacko LA, Chandar V, Bram Y, Zhang T, Zhang W, He F, Pan C, Wu J, Huang Y, Evans T, van der Valk P, Titulaer MJ, Spoor JKH, Furler O'Brien RL, Bugiani M, W DJVdB, Schwartz RE^*, Ho DD^*, Studer L^* and Chen S^*. SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell Stem Cell. 2024.
9. Yang L^#, Nilsson-Payant BE^#, Han Y^#, Jaffré F^#, Zhu J^#, Wang P, Zhang T, Redmond D, Houghton S and Møller R, Hoagland D, Carrau L, Horiuchi S, Goff M, Lim JK, Bram Y, Richardson C, Chandar V, Borczuk A, Huang Y, Xiang J, Ho DD^*, Schwartz RE^*, tenOever BR, Evans T^* and Chen S^*. Cardiomyocytes Recruit Monocytes upon SARS-CoV-2 Infection by Secreting CCL2. Stem Cell Reports. 2021 Jul 20.
10. Yang L^#, Han Y^#, Zhou T^#, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C, Giani AM, Li Y, Dong X, Moroziewicz D, Team NGSCA, Paull D, Chen Z, Zhong A, Noggle SA, Rice CM, Qi Q, Evans T and Chen S^*. Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection. iScience. 2023;26:107001.